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When c-Met is activated by HGF, PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate after Gab1 coupled to the p85 subunit, which ultimately leads to phosphorylation of c-Met (Sheng et al., 2003
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Martín et al., 2021), inhibition of spore development (Rossi et al., 2022), DNA damage, and apoptosis induction (Hwang et al., 2012
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