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Social isolation-induced overactivation of the hypothalamus-pituitary-adrenal (HPA) axis further exacerbates neuroinflammation and oxidative stress [12, 13], which may interfere with the physiological maturation and myelination of OLs

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This strategy suits users who achieved satisfactory improvements wanting to preserve results without full continuous intensity, willing to accept moderate benefit levels (70-85% of peak) rather than maximum continuous optimization, seeking to minimize costs while maintaining most improvements, and wanting simpler approach than complex cycling schedules