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30 The suppression of the venous reflux leads to the normalization of several inflammatory mediators in an interesting timing: during the first 2 months after the procedures IL-8, PDGF, EGF, VEGF, and Regulated upon Activation, Normal T Cell Expressed and Presumably Secreted (RANTES) are further increased, possibly as a consequence of the surgical insult and the vascular remodeling, but then, after 6 months, the inflammatory panel normalizes