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The 2-OG carrier (OGC) mediates the exchange of cytosolic GSH and mitochondrial dicarboxylates, including 2-OG [57]
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ROS exerts multiple functions in various pathophysiological responses closely related to augmented NADH/NAD + ratio and accumulation of L-2-hydroxyglutarate, a reductive metabolite that buffers reductive stress via inhibiting glycolysis and the Kreb’s cycle
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