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employed in osteoarthritis and cartilage regeneration research Pigs – Used for pharmacokinetic profiling and oral bioavailability studies Cynomolgus monkeys – 9-month chronic toxicology studies via oral gavage Human subjects – Approximately 900 participants across six clinical trials examining safety and efficacy Research Limitations & Regulatory Status Critical Gaps in Current Evidence Despite over 25 years of research and extensive clinical testing, AOD-9604 faces substantial evidence gaps that have prevented therapeutic development
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The injection delivers methylcobalamin or cyanocobalamin — active forms of B-12 — directly into muscle tissue, where it is quickly utilized by the body
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