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This study will focus on point mutations made to render each of the proposed redox active disulfide pairs inactive
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To identify upstream drivers, we reanalyzed scRNA-seq data from PyMT- TrnE/ND5 tumors and found that S100A8 and S100A9 —key alarmins involved in myeloid cell recruitment 23,24 —were among the top three upregulated genes, along with Lars2 in tumor cells of the moderate-mutant group (Fig
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