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Role of dietary antioxidants in diabetes: An overview - ScienceDirect
Succinimide formation is considered to be caused by nucleophilic attack of the amide nitrogen of the ( N + 1) residue to the amide carbon of the Asn side chain, and proceeds via the tetrahedral intermediate that includes gem -hydroxylamine (Figure 2)
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The increase in free copper is also closely linked to neuroinflammation, as it promotes the activation of microglia and astrocytes, triggering an inflammatory response in the brain, which further exacerbates neuronal damage and cognitive decline (83)
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