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Another target of pJNK phosphorylation in the mouse turns out to be the catalytic subunit of glutamate-cysteine ligase (GCLC), the rate-limiting enzyme of the gamma-glutamyl cycle that is responsible for GSH synthesis
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A previous study have identified a potential therapeutic strategy for LC, demonstrating that N-desmethyl imipramine hydrochloride modulate RBMS1 levels in IR-resistant LC cells, thereby enhancing their susceptibility to radiation therapy (119)
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