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Combined sedentarism and high-fat diet induce early signs of kidney injury in C57BL/6J mice | American Journal of Physiology-Renal Physiology | American Physiological Society
In addition, inactivating mutations of KEAP1 relieve its suppression of NRF2, and persistently activated NRF2 upregulates a series of antioxidant and detoxification genes, including the glutamate–cysteine ligase subunits GCLC/GCLM and the cytosolic SLC7A11 (83–85)
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Additional work is underway to determine the extent of IgG deposition in the brains of exposed offspring, including region-specific distribution patterns, the range of affected cell types, and the extent to which this differs between treatment and control animals across the lifespan
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