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We therefore speculate that lenticular cysteine transport from aqueous humor occurs, most likely via a sodium-dependent transporter system, such as EAAC1, and that high cysteine transport activity occurs at the lens equator region, as reported by Truscott’s group(Sweeney et al., 2003)
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Studies show that MDA levels significantly increase in IL-1β- or erastin-induced OA mouse models, while 4-HNE and its protein adducts rise in the synovial fluid and chondrocytes of OA patients, underscoring the critical role of lipid peroxidation in OA pathology (Shah et al., 2005
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