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For example, IMiDs derivatives for click-chemistry can be constructed by S N Ar reactions between amine-terminal alkine or azide-based linkers and fluorinated thalidomide derivatives, leading to compound 119 83,132,171
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96,97 Heavy metals such as manganese and cadmium show clear dose-dependent neurotoxicity in both humans and animal models, with elevated blood or urinary levels correlating with impaired mitochondrial biogenesis and motor dysfunction
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