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Once corrosion cast microscopy methods became available, studies into vascular changes within the myometrium in the presence of uterine fibroids indeed found venous lakes enlarged in uteri bearing fibroids in comparison to normal uteri (89), and further support to the theory was lent by immunohistochemistry studies of cyclic changes in uterine vasculature showing dilated and disintegrating venous vessels in the upper functionalis layer of the endometrium (90), showing that menstrual blood was largely venous in origin