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5.1 Pharmacological effects 5.1.1 NMDAR antagonism Ketamine exerts its primary effects by acting as a noncompetitive antagonist of NMDARs and reducing glutamate-mediated excitatory neurotransmission (Franks and Lieb, 1994
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In neurons specifically, this pathway supports the formation of new synaptic connections and the maintenance of existing neural circuits
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